Giuliana Rancic in Great Spirits at Fan Meet & Greet Event (PHOTOS)

Giuliana Rancic is looking better than ever. The E! News host, who underwent a double mastectomy and reconstructive surgery two weeks ago, looked happy as she and her hubby Bill Rancic headed to a fan signing in Santa Monica on Thursday afternoon. The adorable couple held hands and seemed in great spirits — even stopping to pose with a fan’s adorable baby. Aww!

Although she has put the spotlight on a very vulnerable time in her life, the 37-year-old E! News host told Celebuzz that she doesn’t regret her choice.

“Well, you have to expect that people will come up to you and ask you all sorts of personal questions — even on days when you don’t feel like talking. But at the same time, I think about how incredibly rewarding it has all been… It’s sweet that we’ve been able to help people going through the same things,” she said, referring to both her surgery and IVF troubles.

Yesterday, Giuliana returned to her job at E! News reporting on all the latest celebrity news from Ashton Kutcher’s new rumored romance to Teen Mom drama. After the show, she told E!, “It feels great to be back at work. I wasn’t sure whether I was going to return to E! News this week or after the new year. The last thing I wanted to do was rush my recovery.”

She added: “Thankfully, I’ve been feeling better every single day since surgery and this weekend my doctors gave me the green light to get back to work. Even though I moved a tad slower than usual today, everyone welcomed me back with open arms and it was a wonderful homecoming.”