Nora Ephron Dead: Tom Hanks, Meg Ryan Remember 'Sleepless in Seattle' Scribe (PHOTOS)

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Hollywood is mourning the loss of Nora Ephron, the brilliant writer-director who helped bring some of the most memorable romantic comedies to the big screen in her decades-plus career.

Ephron -- who died Tuesday evening in New York of acute myeloid leukemia, a blood disease she was diagnosed with six years ago -- worked with some of the biggest names in movies after she transitioned from journalism to show business.

Now, many of them are offering their condolences in the hours after her death.

Celebuzz has compiled a gallery of some of most notable responses, including ones from Tom Hanks, who worked with Eprhon on the 1993 romantic comedy Sleepless in Seattle, and Meryl Streep, who earned an Oscar nomination for her portrayal of cooking legend Julia Child in Eprhon's 2009 hit Julie & Julia.

We've also pulled together five of our favorite moments from Ephron's long and successful filmography, which included such hits as When Harry Met Sally ... in 1999, and Sleepless in Seattle in 1993.

Check them out below:

5.) Julia Child Flips Out

In Julia & Julia, Eprhon crafted a parallel story between up-and-coming chef Julia Child (Meryl Streep) and a modern-day New Yorker (Amy Adams) who aimed to cook every recipe in Child's now-famous book, 'Mastering the Art of French Cooking.' In the scene below, check out Streep's uncanny portrayal of Child, which earned the actress her 16th of 17 Oscar nominations.

4.) You've Got Romance

After developing an online romance with a mysterious -- but charming -- man, local bookshop owner Kathleen (Meg Ryan) realizes that the man she's fallen in love with is her business rival, Joe (Tom Hanks). Watch the You've Got Mail scene below:

3.) Karen Silkwood Contaminated

Ephron earned her first of three Oscar nominations for penning the 1983 classic Silkwood, about a chemical technician (Meryl Streep) who investigates her plant's faulty safety methods after she and her coworkers become contaminated with radiation. The film was based on the true story of Karen Silkwood, who died in a suspicious car accident during her investigation.

2.) "You're Annie"

An engaged Baltimore journalist (Meg Ryan) finds herself obsessed with a widowed father (Tom Hanks) -- and the movie An Affair to Remember -- after she hears his tragic story on a syndicated radio show. Their love affair culminates when they accidentally meet each other atop the Empire State Building in Sleepless in Seattle.

1.) "I'll Have What She's Having"

In what quickly became one of the most memorable movie scenes of all time, friends Harry (Billy Crystal) and Sally (Meg Ryan) debate whether men can actually tell when a woman is, you know, faking it.

Share your favorite Nora Ephron movie moments in the comments, below!

In a statement obtained Tuesday, the family of Ephron confirmed her death, saying:

Nora Ephron passed away June 26, 2012 at 7:40 pm at New York Presbyterian/Weill Cornell Medical Center surrounded by her family. The cause of death was acute myeloid leukemia. She was 71.

Donations can be made in her honor to The Public Theater and The Motion Picture and Television Fund.

We thank you all for your thoughts.

 

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