‘Grey’s Anatomy’s’ Jesse Williams on Losing Cast Members: ‘It Was Very Difficult’ (VIDEO)

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Be prepared Grey’s fans, Jesse Williams tells us that this season of ABC’s Grey’s Anatomy is only going to get crazier.

When Celebuzz caught up with Williams at the 21st annual Montblanc de la Culture Arts Patronage Ceremony honoring Quincy Jones on Tuesday, he told us the loss of Mark (Eric Dane) and Lexie (Chyler Leigh) on the show was just as difficult for the cast and crew as it was for the fans.

“It was very difficult for us at the end of last year and the beginning of this one. These people, this is our crew,” Williams, who plays Jackson Avery on the show, told us.

Things will be particularly interesting for Jackson this season as he not only lost his ex-girlfriend in the devastating plane crash but also his mentor. Last week’s premiere featured a heartbreaking scene of Jackson asking a coma-stricken Mark for advice on their patients.

What else did the actor say was in store for his character in Season 9?

“He’s got to deal with the issue of Richard Webber [James Pickens, Jr.] sleeping with his mom,” revealed Williams, “and a new love interest in his life that’s also his close friend, if that’s going to work, there’s a lot of push and pull there.”

That new love interest would be April Kempner (Sarah Drew). At the end of last season, Jackson and April got it on during their boards despite her religiousness and virginity. It looks like things might be headed into the extremely serious zone as a spoiler filled trailer for the season showed him asking her an important question.

Despite the loss of some major characters, Williams also mentioned how great it’s been working with the fresh blood on the show, including new interns – Tina Majorino, Gaius Charles and Camilla Luddington.

As he was once the new kid in the hospital, what advice does he have for his new co-stars?

“Keep your head down. One episode at a time. Do your work. Observe. We’re really lucky to have the crop of actors [we do] on the show. Really, really talented folks,” he said humbly. “And you know, I’m not in much of a position to give much advice because they’ve probably been acting longer than I have. But enjoy it.”

Grey’s Anatomy airs Thursdays at 9 PM on ABC.

What do you want to see happen between Jackson and April? Let us know in the comments below!