Watch: The Oscar Host's Funniest Moments...Before The Oscars
Relive Seth MacFarlane's top 10 zingers that made us laugh.
After becoming TV history's youngest executive producer at the age of 24, MacFarlene went on to create The Cleveland Show, American Dad! and write and direct his first feature film, Ted.
Fans and those who hang out in MacFarlene's inner circle know his irreverent wit, musical abilities (he's a regular at Los Angeles' famous Brass Monkey karaoke bar) and impressive pop culture knowledge.
But does he have what it takes to host the Academy Awards Sunday? From a five-word acceptance speech to his dead-on Kermit the Frog impression, relive his top 10 funniest moments and help us decide.
Microphone Fail at the 2012 Emmys: After delivering his presenter's speech into the wrong microphone during 2012's Emmy Awards, MacFarlene quickly saved face and improvised a joke about skipping rehearsal, turning what might've been ho-hum dialogue to one of the most memorable moments of the ceremony.
White Trash Names: MacFarlene may have miffed a lot of girls when they watched this scene from Ted, but those who have encountered not-so-classy ladies of with these monikers were left giggling in their seats.
2007 Emmys Musical Number: If there's one thing MacFarlene fans know, it's that the comedian leaves no stone unturned -- or in the case of the 2007 Emmys, no show safe from ridicule. Providing the voices of Family Guy's Stewie and Brian, MacFarlene sang about how trashy TV has become during the ceremony's opening musical number. Let's just hope the Academy of Motion Picture Arts and Sciences will be able to stomach this kind of humor.
Five-word Acceptance Speech at the Webby Awards: So much LOLs, so little words.
Family Guy's Emmys Campaign: Proving that he's just of a TV fanatic as the rest of America, MacFarlene turned Family Guy's "for Your Consideration" Emmys campaign for Outstanding Comedy in 2009 into a YouTube series YouTube featuring video clips poking fun at the other nominees, including The Office, 30 Rock and -- as seen below -- How I Met Your Mother.
Pizza Salad: If you've ever eaten a salad from a pizza place, you'll get this joke.
Oscars Promo: MacFarlene gave fans a little taste of what's to come when he starred in this Oscars pormo riffing off of old footage from 1999's James Bond flick, The World is Not Enough. "You're gonna have fun."
Acceptance Speech at the 2010 Teen Choice Awards: Hey, if you can't laugh at them. Laugh at yourself. And then maybe laugh at them. And then do a Stewie impersonation.
Kermit the Frog Impression: Even Family Guy's Alex Borstein and Seth Green approved.
And this joke, appropriately about an Oscar nominee: