‘Grey’s Anatomy': The Many Hookups of Alex Karev
Lexie (Chyler Leigh)
Lexie and Alex had a one night stand in Season 4 and have a “friends with benefits” relationship in Season 6. Though she developed feelings for him, he called her Izzie when he was delirious after being shot. Shortly thereafter they were officially done and remained friends until she died in Season 8’s horrific plane crash.